About 11.20am today (Tuesday 9 November), officers attached to Blacktown Police Area Command attended a home on Bulah Way, Seven Hills, to conduct inquiries in relation to an outstanding warrant.
A physical confrontation ensued and a man was shot by police.
Officers conducted CPR until the arrival of NSW Ambulance paramedics who worked on the man, but he could not be revived.
A crime scene has been established and inquiries are underway.
A number of residential streets have been closed with diversions in place.
Police have not released further information at this time.